Article
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome.
Investigative ophthalmology & visual science - 1 Feb 2003
Levinson Ralph D, Park Min S, Rikkers Sarah M, Reed Elaine F, Smith Justine R, Martin Tammy M, Rosenbaum James T, Foster C Stephen, Sherman Mark D, Holland Gary N
Abstract excerpt
PURPOSE: To identify genetic markers for the tubulointerstitial nephritis and uveitis (TINU) syndrome by using human leukocyte antigen (HLA) genotyping. METHODS: Eighteen patients who had TINU syndrome were evaluated at three institutions. Typing of class I and II genes was performed by using DNA-based techniques. RESULTS: Significant associations were found with HLA-B14 (6/18 patients, 33.3%; control subjects,...
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