Article
The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily.
Recent progress in hormone research - 1 Jan 1996
Burris T P, Guo W, McCabe E R
Abstract excerpt
X-linked adrenal hypoplasia congenita (AHC) is an inherited disorder of the development of the adrenal cortex. The gene responsible for this genetic disorder has been identified using positional cloning methods and has been named DAX-1 based on its localization within the dosage-sensitive sex rev...
Topics
- Adrenal Insufficiency
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- DAX-1 Orphan Nuclear Receptor
- DNA-Binding Proteins
- Gene Expression
- Genetic Linkage
- Humans
- Molecular Sequence Data
- Mutation
- Receptors, Retinoic Acid
- Repressor Proteins
- Transcription Factors
- X Chromosome