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Article

Dual regulation of upstream binding factor 1 levels by IRS-1 and ERKs in IGF-1-receptor signaling.

Journal of cellular physiology - 1 Sept 2007

Sun Hongzhi, Tu Xiao, Liu Mingli, Baserga Renato

Abstract excerpt

The Upstream Binding Factor 1 (UBF1) is a nucleolar protein that participates in the regulation of RNA polymerase I activity and ribosomal RNA (rRNA) synthesis. In 32D myeloid cells expressing the type 1 insulin-like growth factor receptor (IGF-IR), the UBF1 protein (but not its mRNA) is down regulated when the cells are shifted from Interleukin-3 (IL-3) to IGF-1. Ectopic expression of insulin receptor...

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PMID: 17443674
DOI: 10.1002/jcp.21072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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