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HPV16 E6 and E7 oncoproteins regulate Notch‐1 expression and cooperate to induce transformation

23 Jan 2003

Abstract excerpt

Notch receptor signaling has been implicated in cellular transformation. Notch-1 receptor expression is increased during the progression from cervical intraepithelial lesions (CIN) to invasive cervical carcinoma. Moreover, the main cellular localization of Notch-1 protein changes from cytoplasmic to nuclear with the transition from CIN III to microinvasive carcinoma. Since the E6 and E7 proteins encoded by human...

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PMID: 12548555
DOI: 10.1002/jcp.10217

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