Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In need of high-throughput behavioral systems.

Drug discovery today - 15 Sept 2002

Brunner Dani, Nestler Eric, Leahy Emer

Abstract excerpt

One of the current major bottlenecks in drug discovery is in vivo testing of candidate drugs in behavioral paradigms in normal or genetically altered mice. This testing is essential in discovering gene function and predicting potential efficacy of CNS drugs in humans. New efforts in the biotech community aim to alleviate this bottleneck by developing higher-throughput systems of behavioral, neurological and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Drug Evaluation, Preclinical
Share to Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Mice, Mutant Strains

Share to Phenotype

Source

Identifiers

PMID: 12546875
DOI: 10.1016/s1359-6446(02)02423-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In need of high-throughput behavioral systems.PMID 12546875Read ↗

High-throughput analysis of behavior for drug discovery.Semantic proximity Read ↗

Behavioral phenotyping strategies for mutant mice.Semantic proximity Read ↗

Behavioral phenotyping of rodents.Semantic proximity Read ↗

The fallacy of behavioral phenotyping without standardisation.Semantic proximity Read ↗

Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing.Semantic proximity Read ↗

Dissecting complex behaviours in the post-genomic era.Semantic proximity Read ↗

AHCODA-DB: a data repository with web-based mining tools for the analysis of automated high-content mouse phenomics data.Semantic proximity Read ↗

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST).Semantic proximity Read ↗

A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice.Semantic proximity Read ↗

Model organism databases in behavioral neuroscience.Semantic proximity Read ↗

A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants.Semantic proximity Read ↗

Using the zebrafish photomotor response for psychotropic drug screening.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.