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Article

Morphological and genetic differences in two isogenic Staphylococcus aureus strains with decreased susceptibilities to vancomycin.

Antimicrobial agents and chemotherapy - 1 Feb 2003

Reipert Andrea, Ehlert Kerstin, Kast Thomas, Bierbaum Gabriele

Abstract excerpt

Many VISA (vancomycin intermediately resistant Staphylococcus aureus) strains are characterized by increased cell wall biosynthesis and decreased cross-linking of the peptide side chains, leading to accumulation of free D-alanyl-D-alanine termini in the peptidoglycan, which act as false target sites for vancomycin. A spontaneous mutant of methicillin-resistant VISA strain SA137/93A (vancomycin MIC [E-test], 8...

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Identifiers

PMID: 12543661
DOI: 10.1128/AAC.47.2.568-576.2003
PMCID: PMC151770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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