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Article

Modulation of J774.1 macrophage L-arginine metabolism by intracellular Mycobacterium bovis BCG.

Infection and immunity - 1 Feb 2003

Peteroy-Kelly Marcy A, Venketaraman Vishwanath, Talaue Meliza, Seth Anjali, Connell Nancy D

Abstract excerpt

Using a Mycobacterium bovis BCG mutant (AS1) lacking a Bacillus subtilis L-arginine transporter homolog, we demonstrate here that the interaction between intracellular mycobacteria and the macrophage with respect to L-arginine transport and metabolism is quite complex. Intracellular AS1 stimulates macrophage L-arginine transport and accumulates 2.5-fold more (3)H label derived from L-arginine than does the wild...

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Identifiers

PMID: 12540586
DOI: 10.1128/IAI.71.2.1011-1015.2003
PMCID: PMC145349

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Source receipt: pubmed, retrieved 7 Sept 2026.

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