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Article

Sensitivity of Polarized Epithelial Cells to the Pore-Forming Toxin Aerolysin

22 Jan 2003

Abstract excerpt

Aerolysin is one of the major virulence factors produced by Aeromonas hydrophila, a human pathogen that produces deep wound infection and gastroenteritis. The toxin interacts with target mammalian cells by binding to the glycan core of glycosylphosphatidyl inositol (GPI)-anchored proteins and subsequently forms a pore in the plasma membrane. Since epithelial cells of the intestine are the primary targets of...

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Identifiers

PMID: 12540553
DOI: 10.1128/iai.71.2.739-746.2003

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