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Article

Normal tissue depresses while tumor tissue enhances human T cell responses in vivo to a novel self/tumor melanoma antigen, OA1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2003

Touloukian Christopher E, Leitner Wolfgang W, Schnur Rhonda E, Robbins Paul F, Li Yong, Southwood Scott, Sette Alessandro, Rosenberg Steven A, Restifo Nicholas P

Abstract excerpt

Antitumor T cells often recognize targets that are nonmutated "self" tissue differentiation Ags, but the relative impact of Ag expression by normal and transformed tissue for a human self/tumor Ag has not been studied. To examine the influence of self-tolerance mechanisms on the function of self/tumor-specific T cell responses in humans, we sought to identify an Ag that was expressed, processed, and presented in...

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Identifiers

PMID: 12538723
DOI: 10.4049/jimmunol.170.3.1579
PMCID: PMC2241741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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