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Article

Methylenetetrahydrofolate reductase gene C677T mutation is related to the defects in the internal elastic lamina of the artery wall.

European journal of clinical investigation - 1 Dec 2002

Hämelahti P, Järvinen O, Sisto T, Wirta V, Ilveskoski E, Koivula T, Lehtimäki T

Abstract excerpt

BACKGROUND: The C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene leads to C/C, C/T and T/T genotypes, which affect the plasma homocysteine concentration in humans. In mini-pigs, high serum homocysteine levels are associated with defects in the internal elastic lamina (IEL) of the artery wall, which are apparently related to the migration of smooth muscle cells into the intima during...

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Source

Identifiers

PMID: 12534444
DOI: 10.1046/j.1365-2362.2002.01050.x

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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