Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-MYC apoptotic function is mediated by NRF-1 target genes.

Genes & development - 15 Jan 2003

Morrish Fionnuala, Giedt Christopher, Hockenbery David

Abstract excerpt

A detailed understanding of the signaling pathways by which c-Myc elicits apoptosis has proven elusive. In the current study, we have evaluated whether the activation of the mitochondrial apoptotic signaling pathway is linked to c-Myc induction of a subset of genes involved in mitochondrial biogenesis. Cytochrome c and other nuclear-encoded mitochondrial genes are regulated by the transcription factor nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Cell Division
Share to Cytochrome c Group

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, myc

Share to Microscopy, Electron

Share to Mitochondria

Share to Trans-Activators

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 12533512
DOI: 10.1101/gad.1032503
PMCID: PMC195978

Genes

GCG
MAX
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

c-MYC apoptotic function is mediated by NRF-1 target genes.PMID 12533512Read ↗

CREB1 controls mitochondrial dysfunction in 1-nitropyrene-mediated apoptosis of human bronchial cells and lung injurySemantic proximity Read ↗

Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In VivoSemantic proximity Read ↗

Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphomaSemantic proximity Read ↗

p53 has a direct apoptogenic role at the mitochondria.Semantic proximity Read ↗

Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release.Semantic proximity Read ↗

Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis.Semantic proximity Read ↗

Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster.Semantic proximity Read ↗

Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancerSemantic proximity Read ↗

CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.