Article
Requirement for Lim1 in head-organizer function.
Nature - 30 Mar 1995
Shawlot W, Behringer R R
Abstract excerpt
Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining bo...
Topics
- Animals
- Base Sequence
- Biomarkers
- Brain
- DNA Primers
- Embryonic Induction
- Embryonic and Fetal Development
- Gene Deletion
- Gene Expression
- Gene Targeting
- Genes, Homeobox
- Head
- Homeodomain Proteins
- LIM-Homeodomain Proteins
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data