Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement for Lim1 in head-organizer function.

Nature - 30 Mar 1995

Shawlot W, Behringer R R

Abstract excerpt

Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to DNA Primers
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Base Sequence

Share to Mice, Inbred C57BL

Share to Molecular Sequence Data

Source

Identifiers

PMID: 7700351
DOI: 10.1038/374425a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for Lim1 in head-organizer function.PMID 7700351Read ↗

A study of Xlim1 function in the Spemann-Mangold organizer.Semantic proximity Read ↗

Requirement of LIM domains for LIM1 function in mouse head development.Semantic proximity Read ↗

Conserved requirement of Lim1 function for cell movements during gastrulation.Semantic proximity Read ↗

Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.Semantic proximity Read ↗

Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo.Semantic proximity Read ↗

Snail1 gene function during early embryo patterning in mice.Semantic proximity Read ↗

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.Semantic proximity Read ↗

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.Semantic proximity Read ↗

Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.Semantic proximity Read ↗

Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo.Semantic proximity Read ↗

Functions of LIM-homeobox genes.Semantic proximity Read ↗

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.