Article
Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer.
Anticancer research - 1 Jan 2000
Takagi Sho, Kinouchi Yoshitaka, Hiwatashi Nobuo, Hirai Masashi, Suzuki Susumu, Takahashi Seiichi, Negoro Kenichi, Obana Nobuya, Shimosegawa Tooru
Abstract excerpt
AIM: The aim of this study was to examine whether and relationships could be found among polymorphism of the NQO1 gene, telomere length and telomerase activity in colorectal cancers. MATERIALS AND METHODS: Fifty-one invasive colorectal cancers were studied. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was undergone to detect mutation of the NQO1 gene. Telomere length was...
Topics
- Aged
- Colorectal Neoplasms
- Female
- Humans
- Male
- Mutation
- NAD(P)H Dehydrogenase (Quinone)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length