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Article

Development of a replication-selective, oncolytic poxvirus for the treatment of human cancers.

Cancer gene therapy - 1 Dec 2002

Zeh Herbert J, Bartlett David L

Abstract excerpt

Tumor directed gene therapy for the purpose of destroying cancer cells through replicative "oncolysis" or by intratumoral expression of toxic or immunostimulatory genes requires an efficient, tumor targeted vector. Vectors are limited by inefficient replication in vivo, inefficient tumor targeting, and safety concerns. As a unique approach to addressing these limitations, our laboratory has studied poxviruses as...

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PMID: 12522439
DOI: 10.1038/sj.cgt.7700549

Genes

VGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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