Article
Inferring the rate and time-scale of dengue virus evolution.
Molecular biology and evolution - 1 Jan 2003
Twiddy S Susanna, Holmes Edward C, Rambaut Andrew
Abstract excerpt
Dengue is often referred to as an emerging disease because of the rapid increases in incidence and prevalence that have been observed in recent decades. To understand the rate at which genetic diversification occurs in dengue virus and to infer the time-scale of its evolution, we employed a maximum likelihood method that uses information about times of virus sampling to estimate the rate of molecular evolution in...
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