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Article

The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk.

International journal of cancer - 1 Mar 2003

Chang-Claude Jenny, Dunning Alison, Schnitzbauer Udo, Galmbacher Petra, Tee Louise, Wjst Matthias, Chalmers Jennifer, Zemzoum Iris, Harbeck Nadia, Pharoah Paul D P, Hahn Heidi

Abstract excerpt

The gene coding for the human homologue of the Drosophila segment polarity gene patched (PTCH1) is mutated in several common human tumors. In mice, haplodeficiency at the Ptch1 locus results in severe histologic defects in mammary ductal structure. We found no mutations within the coding region of PTCH1 in 17 human primary breast carcinomas. However, the biallelic Pro1315Leu (C3944T) polymorphism of PTCH1 was...

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Source

Identifiers

PMID: 12516098
DOI: 10.1002/ijc.10889

Genes

PTCH1
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk.PMID 12516098Read ↗

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