Article
Hereditary keratoconus-like keratopathy in Japanese wild mice mapped to mouse Chromosome 13.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2002
Tachibana Masayoshi, Okamoto Mieko, Sakamoto Michihiro, Matsushima Yoshibumi
Abstract excerpt
Human keratoconus is a common corneal disease with non-inflammatory corneal ectasia, and a subset of this disease is heritable. In an effort to establish animal models for this disease, we discovered Japanese keratoconus (JKC) mice among Mishima molosinus (MSM) mice, an inbred strain of Japanese wild mice (Mus musculus molossinus). Typical phenotypic corneas of JKC mice are, like human keratoconus, conical in...
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