Article
Mapping of genes involved in murine herpes simplex virus keratitis: identification of genes and their modifiers.
Journal of virology - 1 Apr 2002
Norose Kazumi, Yano Akihiko, Zhang Xiang-Ming, Blankenhorn Elizabeth, Heber-Katz Ellen
Abstract excerpt
Herpes simplex keratitis (HSK) is an inflammatory response to viral infection and self antigens in the cornea and is a major cause of blindness. Using two strains of mice which are susceptible (129/SVEV) and resistant (C57BL/6) to herpes simplex virus (HSV) strain KOS, (129/SVEV x C57BL/6)F(2) mice were generated and examined for their disease susceptibility in terms of clinical symptoms, ocular disease, and...
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