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Article

A novel streptococcal surface protease promotes virulence, resistance to opsonophagocytosis, and cleavage of human fibrinogen.

The Journal of clinical investigation - 1 Jan 2003

Harris Theresa O, Shelver Daniel W, Bohnsack John F, Rubens Craig E

Abstract excerpt

Group B streptococcus (GBS) is an important human pathogen. In this study, we sought to identify mechanisms that may protect GBS from host defenses in addition to its capsular polysaccharide. A gene encoding a cell-surface-associated protein (cspA) was characterized from a highly virulent type III GBS isolate, COH1. Its sequence indicated that it is a subtilisin-like extracellular serine protease homologous to...

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Identifiers

PMID: 12511589
DOI: 10.1172/JCI16270
PMCID: PMC151836

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Source receipt: pubmed, retrieved 7 Sept 2026.

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