Development of Methicillin Resistance in Clinical Isolates of <i>Staphylococcus sciuri</i> by Transcriptional Activation of the <i>mecA</i> Homologue Native to the Species

Abstract excerpt

The beta-lactam resistance gene mecA was acquired by Staphylococcus aureus from an extraspecies source. The search for the possible origin of this gene has led to the identification of a close structural homologue of mecA as a native gene in the animal species Staphylococcus sciuri. Surprisingly, the overwhelming majority of S. sciuri isolates were fully susceptible to beta-lactam antibiotics in spite of the...

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