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Article

Evolutionary Origin of the Staphylococcal Cassette Chromosome mec (SCCmec).

Antimicrobial agents and chemotherapy - 1 Jun 2017

Rolo Joana, Worning Peder, Nielsen Jesper Boye, Bowden Rory, Bouchami Ons, Damborg Peter, Guardabassi Luca, Perreten Vincent, Tomasz Alexander, Westh Henrik, de Lencastre Hermínia, Miragaia Maria

Abstract excerpt

Several lines of evidence indicate that the most primitive staphylococcal species, those of the Staphylococcus sciuri group, were involved in the first stages of evolution of the staphylococcal cassette chromosome mec (SCCmec), the genetic element carrying the β-lactam resistance gene mecA However, many steps are still missing from this evolutionary history. In particular, it is not known how mecA was...

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Identifiers

PMID: 28373201
DOI: 10.1128/AAC.02302-16
PMCID: PMC5444190

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