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Article

High frequency and diversity of cassette chromosome recombinases (ccr) in methicillin-susceptible Staphylococcus sciuri.

The Journal of antimicrobial chemotherapy - 1 Jun 2014

Rolo Joana, de Lencastre Hermínia, Miragaia Maria

Abstract excerpt

OBJECTIVES: Previous studies produced evidence that mecA, the determinant of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA), may have originated in the most primitive and widespread animal commensal species-Staphylococcus sciuri. But how the mecA homologue (mecA1/pbpD) was captured from S. sciuri into the staphylococcal cassette chromosome mec (SCCmec) has remained unclear. METHODS: To...

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PMID: 24535274
DOI: 10.1093/jac/dku028

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