Article
Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation.
Blood - 1 May 2003
Shilling Heather G, McQueen Karina L, Cheng Nathalie W, Shizuru Judith A, Negrin Robert S, Parham Peter
Abstract excerpt
Interactions between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands influence development of natural killer (NK) cell repertoire and response to infection, cancer, and allogeneic tissue. As KIRs and HLA class I molecules are highly polymorphic, clinical allogeneic hematopoietic cell transplantation is predicted to frequently involve KIR mismatch, and thus to provide...
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