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Article

Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype.

International journal of molecular sciences - 7 Sept 2022

Schira-Heinen Jessica, Wang Luzhou, Akgün Seda, Blum Sofia, Ziegler Brigida, Heinen André, Hartung Hans-Peter, Küry Patrick

Abstract excerpt

Transdifferentiation of Schwann cells is essential for functional peripheral nerve regeneration after injury. By activating a repair program, Schwann cells promote functional axonal regeneration and remyelination. However, chronic denervation, aging, metabolic diseases, or chronic inflammatory processes reduce the transdifferentiation capacity and thus diminish peripheral nerve repair. It was recently described...

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Identifiers

PMID: 36142246
DOI: 10.3390/ijms231810311
PMCID: PMC9499684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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