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Article

In human fetal astrocytes exposure to interleukin-1 beta stimulates acquisition of the GD3+ phenotype and inhibits cell division.

Journal of neurochemistry - 1 Apr 1995

Lee S C, Liu W, Dickson D W, Brosnan C F

Abstract excerpt

In human astrocyte cultures established from second-trimester fetal brain tissue, approximately 5-10% of total astrocyte population in unstimulated cultures were GD3+/glial fibrillary acidic protein (GFAP)+. The GD3+ cells were always GFAP+ and grew as flat, highly spread cells but changed to process-bearing cells after interleukin-1 beta (IL-1 beta) stimulation. It is interesting that IL-1 beta, a known mitogen...

Topics

Astrocytes
Blood Physiological Phenomena
Cell Count
Cell Division
Cells, Cultured
Cytokines
Fetus
Gangliosides
Humans
Interleukin-1
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7891108
DOI: 10.1046/j.1471-4159.1995.64041800.x

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7891108-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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