Article
Autoregulation in the biosynthesis of ribosomes.
Molecular and cellular biology - 1 Jan 2003
Zhao Yu, Sohn Jung-Hoon, Warner Jonathan R
Abstract excerpt
The synthesis of ribosomes in Saccharomyces cerevisiae consumes a prodigious amount of the cell's resources and, consequently, is tightly regulated. The rate of ribosome synthesis responds not only to nutritional cues but also to signals dependent on other macromolecular pathways of the cell, e.g., a defect in the secretory pathway leads to severe repression of transcription of both rRNA and ribosomal protein...
Topics
- Blotting, Northern
- Cytoplasm
- DNA Primers
- Gene Deletion
- Gene Expression Regulation, Fungal
- Models, Genetic
- Mutation
- Phenotype
- Plasmids
- Protein Binding
- Protein Biosynthesis
- RNA
- RNA, Messenger
- RNA, Ribosomal
- Ribosomal Proteins
- Ribosomes
- Saccharomyces cerevisiae
- Temperature