Article
Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death.
Molecular and cellular biology - 1 Jan 2003
Ono Koh, Kim Sung O, Han Jiahuai
Abstract excerpt
Since a release of intracellular contents can induce local inflammatory responses, mechanisms that lead to loss of plasma membrane integrity in cell death are important to know. We showed previously that deficiency of the plasma membrane Ca2+ ATPase 4 (PMCA4) in L929 cells impaired tumor necrosis factor alpha (TNF-alpha)-induced enlargement of lysosomes and reduced cell death. The lysosomal changes can be...
Topics
- Adenosine Triphosphate
- Animals
- Apoptosis
- Cell Death
- Cell Line
- Cell Membrane
- Cell Survival
- DNA
- Humans
- Jurkat Cells
- Lysosomes
- Mice