Article
Hemoglobin Görwihl [alpha2beta(2)5(A2)Pro-->Ala], an electrophoretically silent variant with impaired glycation.
Clinical chemistry - 1 Jan 2003
Bissé Emmanuel, Schauber Claude, Zorn Nathalie, Epting Thomas, Eigel Antonin, Van Dorsselaer Alain, Wieland Heinrich, Kister Jean, Kiger Laurent
Abstract excerpt
BACKGROUND: Some of the genetic variants of hemoglobin (Hb) and their chemically modified species are known to affect the measurement of Hb A(1c). The purpose of this study was to characterize Hb species in the blood sample of a 74-year-old German male with an exceptionally low Hb A(1c) value. METHODS: Hemolysates from the propositus and a healthy individual were analyzed by electrophoresis, cation-exchange HPLC,...
Topics
- Aged
- Chromatography, High Pressure Liquid
- Electrophoresis, Agar Gel
- Female
- Glucose
- Glycated Hemoglobin
- Hemoglobins, Abnormal
- Humans
- Isoelectric Focusing
- Male