Article
Hb Cibeles [α2 CD25(B6) (Gly → Asp)]: a novel alpha chain variant causing alpha-thalassemia.
International journal of hematology - 1 Dec 2014
de la Fuente-Gonzalo Félix, Nieto Jorge M, Vinuesa Lara, Sevilla Julián, Díaz-Mediavilla Joaquín, Villegas Ana, González Fernando A, Ropero Paloma
Abstract excerpt
Thalassemias are the most frequent monogenic disorders around the world and are a serious health problem in areas with a high incidence. Thalassemias are particularly frequent in Mediterranean countries, the Middle East, Africa, the Indian subcontinent, and in the Southeast Asia. Of these, α-thalassemia is inherited as an autosomal recessive disorder. α-thalassemias are due to a deficiency or absence of...
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