Article
Effects of hemoglobin (Hb) E and HbD traits on measurements of glycated Hb (HbA1c) by 23 methods.
Clinical chemistry - 1 Aug 2008
Little Randie R, Rohlfing Curt L, Hanson Steve, Connolly Shawn, Higgins Trefor, Weykamp Cas W, D'Costa Mario, Luzzi Veronica, Owen William E, Roberts William L
Abstract excerpt
BACKGROUND: Glycohemoglobin (GHB), reported as hemoglobin (Hb) A(1c), is a marker of long-term glycemic control in patients with diabetes and is directly related to risk for diabetic complications. HbE and HbD are the second and fourth most common Hb variants worldwide. We investigated the accuracy of HbA(1c) measurement in the presence of HbE and/or HbD traits. METHODS: We evaluated 23 HbA(1c) methods; 9 were...
Topics
- Analysis of Variance
- Chromatography, High Pressure Liquid
- Chromatography, Ion Exchange
- Diabetes Mellitus
- Electrophoresis, Capillary
- Genetic Variation
- Glycated Hemoglobin
- Hemoglobin E
- Hemoglobins, Abnormal
- Homozygote
- Humans
- Immunoassay