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Engineered allogeneic mesenchymal stem cells repair femoral segmental defect in rats

30 Dec 2002

Abstract excerpt

Bone marrow derived mesenchymal stem cells (MSC) have been shown to be progenitor cells for mesenchymal tissues. These cells may also provide a potential therapy for bone repair. Our previous studies showed that MSC engineered with the gene for bone morphogenetic protein 2 (BMP-2), a growth factor for bone cells, were capable of differentiating into osteoblast lineage and inducing autologous bone formation in...

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PMID: 12507579
DOI: 10.1016/s0736-0266(02)00108-0

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