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Exogenously Regulated Stem Cell-Mediated Gene Therapy for Bone Regeneration

1 Apr 2001

Abstract excerpt

Regulated expression of transgene production and function is of great importance for gene therapy. Such regulation can potentially be used to monitor and control complex biological processes. We report here a regulated stem cell-based system for controlling bone regeneration, utilizing genetically engineered mesenchymal stem cells (MSCs) harboring a tetracycline-regulated expression vector encoding the osteogenic...

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Identifiers

PMID: 11319905
DOI: 10.1006/mthe.2001.0291

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