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Article

Niemann-Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tangles.

Neurobiology of disease - 1 Nov 2002

Bu Bitao, Klunemann Hans, Suzuki Kinuko, Li Jin, Bird Thomas, Jin Lee-Way, Vincent Inez

Abstract excerpt

It is unknown why cerebellar neurons resist neurofibrillary tangle (NFT) formation. In Niemann-Pick disease Type C (NPC), NFT-mediated neurodegeneration occurs throughout brain, but the cerebellum degenerates conspicuously without NFT. To understand why, we have studied markers of NFT pathogenesis in cerebellum from 17 NPC cases, all having abundant NFT in forebrain. Remarkably, we found that NPC cerebella...

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Identifiers

PMID: 12505421
DOI: 10.1006/nbdi.2002.0551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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