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Article

Residues involved in the catalysis, base specificity, and cytotoxicity of ribonuclease from Rana catesbeiana based upon mutagenesis and X-ray crystallography.

The Journal of biological chemistry - 28 Feb 2003

Leu Ying-Jen, Chern Shuenn-Shing, Wang Sui-Chi, Hsiao Ya-Yun, Amiraslanov Imameddin, Liaw Yen-Chywan, Liao You-Di

Abstract excerpt

The Rana catesbeiana (bullfrog) ribonucleases, which belong to the RNase A superfamily, exert cytotoxicity toward tumor cells. RC-RNase, the most active among frog ribonucleases, has a unique base preference for pyrimidine-guanine rather than pyrimidine-adenine in RNase A. Residues of RC-RNase in...

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PMID: 12499382
DOI: 10.1074/jbc.M206701200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12499382-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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