Article
No association between non-violent suicidal behavior and the serotonin transporter promoter polymorphism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2003
Courtet Philippe, Buresi Catherine, Abbar Mocrane, Baud Patrick, Boulenger Jean-Philippe, Castelnau Didier, Mouthon Dominique, Malafosse Alain
Abstract excerpt
There is compelling evidence that suicidal behavior is associated with the dysfunction of the serotonin system. A functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was recently identified and the presence of the short allele was associated with lower gene expression, lower 5-HT uptake and violent suicidal behavior. Thus, we attempted to determine whether 5-HTTLPR is also...
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