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Rheumatic syndromes associated with complement deficiency

1 Jan 2003

Abstract excerpt

Deficiency of an early component of the classical complement pathway, C1q, C1r/C1s, C4, or C2, regularly produces autoimmunity in man, especially systemic lupus erythematosus. It has long been suggested that disruption of this pathway would lead to the inappropriate handling of immune complexes. An intriguing hypothesis that builds on this idea relates to a defect in clearance of one's own cellular debris, namely...

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PMID: 12496511
DOI: 10.1097/00002281-200301000-00010

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