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Article

The effect of GPI-anchor deficiency on apoptosis in mice carrying a Piga gene mutation in hematopoietic cells.

Journal of leukocyte biology - 1 Dec 2002

Kulkarni Shashikant, Bessler Monica

Abstract excerpt

Glycosyl phosphatidylinositol (GPI) anchors are used by a variety of proteins to link to the cell surface. GPI-anchored proteins are deficient on a proportion of blood cells from patients with paroxysmal nocturnal hemoglobinuria. This is caused by the expansion of a cell clone that has acquired a mutation in a gene, PIGA, which is essential in the synthesis of GPI anchors. The nature of the growth/survival...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemoglobinuria, Paroxysmal

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Source

Identifiers

PMID: 12488505

Genes

PIGA
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The effect of GPI-anchor deficiency on apoptosis in mice carrying a Piga gene mutation in hematopoietic cells.PMID 12488505Read ↗

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