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Article

ROLES OF IFN-γ ON STAGE CONVERSION OF AN OBLIGATE INTRACELLULAR PROTOZOAN PARASITE, Toxoplasma Gondii

1 Jan 2002

Abstract excerpt

IFN-gamma downregulates the stage conversion of Toxoplasma gondii (T. gondii), from bradyzoites to tachyzoites, and the expression of heat shock protein 70 (HSP70) of T. gondii (T.g.HSP70) by tachyzoites. T.g.HSP70 has been shown to downregulate NO release from macrophages and also to induce auto-HSP70 antibody formation and IL-10 secretion by VH11-JH1 B-1 cells, resulting in the suppression of host defense...

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PMID: 12486821
DOI: 10.1080/08830180213279

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