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Article

Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer.

Oncogene - 12 Dec 2002

Smith-Sørensen B, Lind G E, Skotheim R I, Fosså S D, Fodstad Ø, Stenwig A-E, Jakobsen K S, Lothe R A

Abstract excerpt

Testicular germ cell tumours are classified into two major histological subgroups, seminomas and nonseminomas. All tumours display several recurrent chromosomal aberrations, but few target genes have been identified. Previous studies have shown that genome-wide hypermethylation of CpG islands is significantly more prevalent in nonseminomas than in seminomas. We have studied two potential target genes in...

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Source

Identifiers

PMID: 12483540
DOI: 10.1038/sj.onc.1205978

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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