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Article

Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution.

Journal of gastroenterology - 1 Jan 2002

Kuwata Kinuko, Hirota Masahiko, Shimizu Hiroyuki, Nakae Masanori, Nishihara Shoji, Takimoto Akio, Mitsushima Kenji, Kikuchi Norihisa, Endo Kazuaki, Inoue Masayasu, Ogawa Michio

Abstract excerpt

BACKGROUND: We hypothesized that mutation of the pancreatic secretory trypsin inhibitor ( PSTI) gene may promote a predisposition to pancreatitis, possibly by reducing the inhibition of trypsin activity. Based on this hypothesis, we performed a biochemical analysis of recombinant PSTI protein. METHODS: The trypsin inhibitory activity of the recombinant protein was analyzed. The activity of PSTI protein with a...

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PMID: 12483248
DOI: 10.1007/s005350200156

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AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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