Article
Racial difference in the activity of the amiloride-sensitive epithelial sodium channel.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 2002
Pratt J Howard, Ambrosius Walter T, Agarwal Rajiv, Eckert George J, Newman Shirley
Abstract excerpt
Compared with whites, blacks appear to retain additional sodium that suppresses secretion of renin and aldosterone. The epithelial sodium channel (ENaC) is an aldosterone-regulated site for sodium reabsorption. ENaC activity could be higher in blacks, contributing to sodium retention or, alternatively, lower because of reduced stimulation by aldosterone. To examine the level of ENaC activity in blacks relative to...
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