Article
Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells.
The Journal of biological chemistry - 21 Feb 2003
Nassar Taher, Sachais Bruce S, Akkawi Sa'ed, Kowalska Maria Anna, Bdeir Khalil, Leitersdorf Eran, Hiss Edna, Ziporen Leah, Aviram Michael, Cines Douglas, Poncz Mortimer, Higazi Abd Al-Roof
Abstract excerpt
Accumulation of low-density lipoprotein (LDL)-derived cholesterol by macrophages in vessel walls is a pathogenomic feature of atherosclerotic lesions. Platelets contribute to lipid uptake by macrophages through mechanisms that are only partially understood. We have previously shown that platelet factor 4 (PF4) inhibits the binding and degradation of LDL through its receptor, a process that could promote the...
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