Article
Mutation and epimutation load in haploid and diploid life forms.
Journal of theoretical biology - 7 Mar 2005
Stenøien Hans K, Pedersen Bård
Abstract excerpt
Epigenetic differentiation is the potentially heritable changes in levels of gene expression not caused by DNA sequence changes. Here, a classification scheme of mutations and epimutations is introduced, enabling a simple analysis of mutation and epimutation load in haploid and diploid organisms. It is found that the deleterious effect of epimutations is mainly determined by epimutation rate and degree of...
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