Article
Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans.
Eukaryotic cell - 1 Jun 2002
Shen Wei-Chiang, Davidson Robert C, Cox Gary M, Heitman Joseph
Abstract excerpt
Cryptococcus neoformans is a pathogenic fungus with a defined sexual cycle involving haploid MATalpha and MATa cells. Interestingly, MATalpha strains are more common, are more virulent than congenic MATa strains, and undergo haploid fruiting in response to nitrogen limitation or MATa cells. Three genes encoding the MFalpha pheromone were identified in the MATalpha mating-type locus and shown to be...
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