Article
Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance.
Journal of clinical microbiology - 1 Dec 2002
Limansky Adriana S, Mussi María Alejandra, Viale Alejandro M
Abstract excerpt
We analyzed the possible causes of imipenem (IPM) resistance in multidrug-resistant isolates of Acinetobacter baumannii. Comparison of the outer membrane protein (OMP) profiles of two genomically related strains (Ab288 [IPM sensitive] and Ab242 [IPM resistant]) indicated the conspicuous loss of a 29-kDa polypeptide in the Ab242 strain. No carbapenemase activity was detected in any of these strains. The treatment...
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