Article
Involvement of a 43-kilodalton outer membrane protein in beta-lactam resistance of Shigella dysenteriae.
Antimicrobial agents and chemotherapy - 1 Oct 1997
Kar A K, Ghosh A S, Chauhan K, Ahamed J, Basu J, Chakrabarti P, Kundu M
Abstract excerpt
A beta-lactam-sensitive strain (C152) of Shigella dysenteriae showed two major outer membrane proteins (OMPs) with M(r)s of 43,000 and 38,000, while the clinical isolate M2 lacked the 43,000-Mr OMP, which acted as a channel for beta-lactam antibiotics. Permeability of beta-lactams across the outer membrane (OM) of M2 was lower than that across the OM of C152. Mutants deficient in the 43-kDa OMP could be selected...
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