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Development of a Real-Time Fluorescence PCR Assay for Rapid Detection of the Diphtheria Toxin Gene

26 Nov 2002

Abstract excerpt

We developed and evaluated a real-time fluorescence PCR assay for detecting the A and B subunits of diphtheria toxin (tox) gene. When 23 toxigenic Corynebacterium diphtheriae strains, 9 nontoxigenic C. diphtheriae strains, and 44 strains representing the diversity of pathogens and normal respiratory flora were tested, this real-time PCR assay exhibited 100% sensitivity and specificity. It allowed for the...

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Share to Clostridium difficile and Clostridium perfringens research
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PMID: 12454177
DOI: 10.1128/jcm.40.12.4713-4719.2002

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