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Improved quadruplex real-time PCR assay for the diagnosis of diphtheria

24 Sept 2019

Abstract excerpt

Introduction. Diphtheria is caused by toxigenic strains of Corynebacterium diphtheriae , Corynebacterium ulcerans and Corynebacterium pseudotuberculosis . For diagnostic purposes, species identification and detection of toxigenic strains (diphtheria toxin ( tox ) - positive strains) is typically performed using end-point PCR. A faster quadruplex real-time PCR (qPCR) was recently developed (De Zoysa et al . J ....

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PMID: 31478826
DOI: 10.1099/jmm.0.001070

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