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Article

Production of thrombopoietin by human carcinomas and its novel isoforms.

Blood - 15 Sept 1999

Sasaki Y, Takahashi T, Miyazaki H, Matsumoto A, Kato T, Nakamura K, Iho S, Okuno Y, Nakao K

Abstract excerpt

Thrombocytosis is occasionally seen in patients with carcinomas and has been assumed to be attributable to interleukin-6 or granulocyte-macrophage colony-stimulating factor produced by carcinoma cells. In this study, we clarified whether thrombopoietin (TPO) is involved in carcinoma-associated thrombocytosis. Expression of TPO mRNA was observed in the majority of 27 carcinoma cell lines as determined by reverse...

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Identifiers

PMID: 10477724

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Production of thrombopoietin by human carcinomas and its novel isoforms.PMID 10477724Read ↗

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Familial Essential Thrombocythemia Associated With One-Base Deletion in the 5′-Untranslated Region of theThrombopoietin GeneSemantic proximity Read ↗

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin geneSemantic proximity Read ↗

Identification of a novel human tissue factor splice variant that is upregulated in tumor cellsSemantic proximity Read ↗

Gene expression and transcriptional regulation of thrombopoietin.Semantic proximity Read ↗

Differential expression of thyroperoxidase mRNA splice variants in human thyroid tumors.Semantic proximity Read ↗

MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth.Semantic proximity Read ↗

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