Article
Sex-related bias and exclusion mapping of the nonrecombinant portion of chromosome Y in human type 1 diabetes in the isolated founder population of Sardinia.
Diabetes - 1 Dec 2002
Contu Daniela, Morelli Laura, Zavattari Patrizia, Lampis Rosanna, Angius Efisio, Frongia Paola, Murru Daniela, Maioli Mario, Francalacci Paolo, Todd John A, Cucca Francesco
Abstract excerpt
A male excess in Sardinian type 1 diabetic cases has previously been reported and was largely restricted to those patients carrying the HLA-DR3/nonDR4 genotype. In the present study, we have measured the male- to-female (M:F) ratio in a sample set of 542 newly collected, early-onset type 1 diabetic Sardinian patients. This data not only confirm the excess of male type 1 diabetic patients overall (M:F ratio = 1.3,...
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